In silico molecular modeling and docking studies on the leishmanial tryparedoxin peroxidase
نویسندگان
چکیده
منابع مشابه
In Silico Molecular Modeling and Docking Studies on the Leishmanial Tryparedoxin Peroxidase
Leishmaniasis is one of the most common form of neglected parasitic disease that affects about 350 million people worldwide. Leishmanias have a trypanothione mediated hydroperoxide metabolism to eliminate endogenous or exogenous oxidative agents. Both of 2-Cys peroxiredoxin (Prx) and glutathione peroxidase type tryparedoxin peroxidase (Px) are the terminal enzymes in the trypanothione dependent...
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Inhibition of the Tryparedoxin peroxidase interaction has been becomes a new therapeutic strategy in leishmaniasis. Docking analysis was carried out to study the effects of quercetin and taxifolin on Tryparedoxin Peroxidase (TryP). Tryparedoxin peroxidase of Trypanosomatidae functions as antioxidants through their Peroxidase and peroxynitrite reductase activities. The 3D models of Tryparedoxin ...
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ژورنال
عنوان ژورنال: Brazilian Archives of Biology and Technology
سال: 2014
ISSN: 1516-8913
DOI: 10.1590/s1516-89132014000200013